|
Symbol Name ID |
Nos3
nitric oxide synthase 3, endothelial cell MGI:97362 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Cor pulmonale |
Cardiomegaly |
Premature coronary artery atherosclerosis |
Stroke |
Ischemic stroke |
Elevated diastolic blood pressure |
Elevated mean arterial pressure |
Elevated systolic blood pressure |
Hypertension |
Raynaud phenomenon |
Pulmonary arterial hypertension |
Sudden cardiac death |
Myocardial infarction |
Abnormality of the vasculature |
Abnormality of the spleen |
Splenic infarction |
Splenomegaly |
Hepatosplenomegaly |
Erythema |
| Disease(s) Associated with NOS3 | |||||||||||||||||||
| Behcet's disease | |||||||||||||||||||
| coronary artery disease | |||||||||||||||||||
| cystic fibrosis | |||||||||||||||||||
| essential hypertension | |||||||||||||||||||
| sickle cell anemia |
| Mouse Phenotypes | cardiovascular system phenotype |
abnormal cardiovascular system morphology |
abnormal pulmonary artery morphology |
abnormal glomerular capillary endothelium morphology |
decreased vascular endothelial cell number |
abnormal induced retina neovascularization |
abnormal lung vasculature morphology |
pulmonary vascular congestion |
abnormal angiogenesis |
abnormal vascular branching morphogenesis |
heart left ventricle hypertrophy |
abnormal heart morphology |
increased heart atrium size |
ostium secundum atrial septal defect |
abnormal interventricular septum morphology |
abnormal interventricular septum membranous part morphology |
muscular ventricular septal defect |
ventricular septal defect |
abnormal heart weight |
increased heart weight |
enlarged heart |
cardiac hypertrophy |
bicuspid aortic valve |
abnormal heart left ventricle morphology |
increased heart left ventricle size |
decreased heart left ventricle posterior wall thickness |
dilated heart left ventricle |
increased heart right ventricle size |
increased heart ventricle size |
increased susceptibility to induced aneurysm formation |
abnormal cardiovascular system physiology |
abnormal blood flow velocity |
abnormal cerebral blood flow rate |
decreased coronary flow rate |
lung hemorrhage |
abnormal pulmonary vascular resistance |
abnormal systemic vascular resistance |
decreased cardiac muscle contractility |
increased cardiac muscle contractility |
increased ventricle muscle contractility |
abnormal cardiac muscle relaxation |
increased fetal cardiomyocyte apoptosis |
increased left ventricle systolic pressure |
abnormal heart right ventricle pressure |
decreased heart rate |
increased heart rate |
abnormal myocardial fiber physiology |
abnormal pulmonary pressure |
pulmonary hypertension |
abnormal systemic arterial blood pressure |
increased systemic arterial blood pressure |
hypertension |
increased mean systemic arterial blood pressure |
increased systemic arterial diastolic blood pressure |
increased systemic arterial systolic blood pressure |
abnormal blood vessel physiology |
abnormal blood-brain barrier function |
abnormal vascular endothelial cell physiology |
decreased vascular permeability |
increased vasoconstriction |
abnormal vasodilation |
decreased vasodilation |
increased vasodilation |
abnormal vascular wound healing |
|
| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Nos3em1(IMPC)Mbp/Nos3em1(IMPC)Mbp | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Nos3tm1.2Taka/Nos3tm1.2Taka | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Nos3tm1Gdk/Nos3tm1Gdk | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Nos3tm1Plh/Nos3tm1Plh | * | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Nos3tm1Unc/Nos3tm1Unc | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Nos3tm1Weo/Nos3tm1Weo | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Nos3tm2.1Plh/Nos3tm2.1Plh | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Nos3tm1Unc/Nos3+ | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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